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[DOI] [PMC free article] [PubMed] [Google Scholar] 126.Ejskjaer N, Vestergaard ET, Hellstrom PM, et al

In endothelial progenitor cells (EPC) derived from human peripheral blood mononuclear cells, high glucose conditions downregulate GLP-1-R and sirtuin 1 ( SIRT1 ) expression, leading to impaired cell functions and increased apoptosis via elevated acetylated p53 levels

Huo YR, Suriyaarachchi P, Gomez F, Curcio CL, Boersma D, Gunawardene P, et al

In obesity-related osteoarthritis, decreased joint compression alone may explain some of the pain improvements reported by patients using GLP-1 medications

Serotonin 2 C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis

Contact your GP if you experience rapid weight gain (more than 2-3 kg within a week), persistent weight gain over several months despite lifestyle adherence, severe abdominal pain, or swelling in the legs and ankles, as these may indicate underlying conditions requiring assessment