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Adults with a BMI of 30 or above, or a BMI of 27 or above with a weight-related health condition such as hypertension, Type 2 diabetes, or high cholesterol, will find Orforglipron an effective option

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The Liraglutide Effect and Action in Diabetes (LEAD)-3 trial included 746 adults (age up to 79 years) with T2D randomised to liraglutide, 1.2 or 1.8 mg, or glimepiride, and found that weight loss following liraglutide did not adversely impact bone mineral density [90], although we do not have data for the impact of liraglutide at 3 mg

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