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This interplay suggests that care structures might benefit from redesign: interdisciplinary teams including nutritionists, psychologists, primary care providers, and social support systems should be considered early in the treatment process to better support behavior change alongside pharmacotherapy

What began with injectable GLP-1 receptor agonists has now evolved into multi-agonist and oral formulations that promise broader access, improved patient compliance, and greater metabolic benefits

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Additionally, weight loss from semaglutide can change metabolic demands, potentially requiring levothyroxine dose adjustments over time

doi: 10.1016/j.phrs.2022.106411