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New England Journal of Medicine 2021,384(11),9891002 Jastreboff, A.M., Aronne, L.J., Ahmad, N.N et al

A reduction in body weight of approximately 5.0 kg over 12 weeks was observed with semaglutide, consistent with previous findings.19 Energy expenditure appeared to be lower with semaglutide vs placebo, though not statistically significant after correcting for lean body mass, suggesting that semaglutideassociated weight loss was not attributable to increased energy expenditure

Mid-cycle blood work at around week 3-4 can identify any concerning trends before they become serious issues