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Less aggressive treatment and worse overall survival in cancer patients with diabetes: a large population based analysis

doi: 10.1038/s41580-021-00350-0

Impairment of insulin signaling pathway PI3K/Akt/mTOR and insulin resistance induced AGEs on diabetes mellitus and neurodegenerative diseases: a perspective review

Pharmacovigilance studies indicate that GLP-1RAs, with the exception of albiglutide, demonstrate potential associations with pancreatic cancer risk, particularly evident in exenatide-treated patients who exhibit elevated cancer incidence rates

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However, after exendin-4 stimulation, the receptor association with clathrin-positive regions increased, an effect that correlates with the known rapid GLP-1R internalisation triggered by exendin-4 (31), with this increase however significantly less pronounced for the GLP-1R V229A compared to WT (F/S = 0.16 0.006 and 0.10 0.004 for WT versus V229A, respectively), in agreement with the reduced internalisation propensity displayed by this mutant receptor (Figure 2H)