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Overall, leptin control of orexin neurons is complex but required for appropriate energy balance
Recent studies have indicated that GLP-1RAs may possess neuroprotective properties (12) and directly reduce ICP
This mirrors some human data where subcutaneous fat responds more consistently to pharmacotherapy than deeper visceral stores during early treatment phases
It also decreases A and phosphorylated tau aggregates in the hippocampus [86]
Ozempic exclusively targets GLP-1 receptors
GLP-1 drugs like semaglutide are used to treat Type 2 diabetes and support weight loss
