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Limiting the analysis to those with a BMI of 35 or higher brought dropout rates down to 8.8% for the low dose and 12.1% for the high dose, compared with 4.8% for the placebo closer to the rates seen in Zepbound trials, but still higher

Semaglutide may enhance vagal signaling, promoting a shift away from sympathetic (fight-or-flight) dominance toward more balanced autonomic function

Therefore, the reduction of foam cells with GLP-1RAs treatment is speculated to inhibit vascular senescence and delay the progression of atherosclerosis

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Since the injection area is subcutaneous, the needle is intended to be smaller, shorter, and finer than others

Statements Author contributions AC and GLG contributed to conception of the review