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According to a 2025 systematic review, retatrutide showed the highest weight loss among all medications studied

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34 Nearly similar pooled proportions of acute pancreatitis, ranging from 0.3% to 0.4%, were reported for all three doses

Non-prescription peptides such as BPC-157 and CJC-1295/Ipamorelin act through entirely different pathways, tissue repair and growth hormone release rather than GLP-1 receptor activation, so they are not true substitutes for Ozempic's mechanism