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It plays a role in digestion, satiety (feeling full), and overall energy balance

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Inflammation-derived oxidative stress and cytokine-dependent toxicity may contribute to nigrostriatal pathway degeneration and hasten disease progression in humans with idiopathic PD [180]

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Similarly, immune dysregulation, poly-endocrinopathy, enteropathy, X-linked (IPEX) syndromea rare, often fatal neonatal autoimmune disorderis caused by mutations in the transcription factor FOXP3, which is critical for Treg development and function