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As a general rule, consultations regarding chemo- or immunotherapy-related cardiotoxicities or pre-stem cell transplant risk stratification may benefit from involvement of cardio-oncology in some form

The researchers suggested the benefits of GLP-1s before pregnancy could be negated or attenuated by the adverse effects of GLP-1 discontinuation. They added the higher risk for gestational weight gain may contribute to the increased risk for hypertensive disorders of pregnancy and gestational diabetes given the established relationship between gestational weight gain and adverse pregnancy outcomes. Maya told Healio that many individuals are on GLP-1s before pregnancy and are benefiting tremendously. Clinicians following these patients need to know that when their patients stop these medications for pregnancy, they are at risk for greater gestational weight gain and greater risk for gestational diabetes, hypertensive disorders of pregnancy and preterm delivery, she said

Gastrointestinal Effects The most commonly reported adverse events in combination research are gastrointestinal, consistent with the mechanisms of both components

Explaining that the boxed warning stems from rodent research helps patients understand why the warning exists

This systemic condition arises predominantly due to the interplay of two key components: (a) compromised insulin production by the pancreatic -cells, and (b) the failure of insulin-sensitive tissues to react to insulin