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GLP-1 RAs induce an increase in heart rate (HR), which, theoretically, represents a safety concern, as this is considered to be associated with higher cardiovascular risk [13, 14]
The effects of orlistat and fenofibrate, alone or in combination, on high-density lipoprotein subfractions and pre-beta1-HDL levels in obese patients with metabolic syndrome
It could also be expected to increase compliance with adjunctive treatments such as behavioral and motivational therapy. Le Roux said the findings need to be validated through randomized controlled trials, especially a trial enrolling adults with alcohol use disorder

There are also less common but important risks, including gallbladder disease, pancreatitis, dehydration from vomiting or diarrhea, worsening reflux or gastroparesis symptoms

GLP-1s have protective effects on liver and kidney function, with measurable improvements in organ health markers

Eating enough is essential to avoid nutrient deficiencies and weight loss stalls