Does GLP-1 worsen chronic migraines?
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The vestibular disorder finding A large real-world study analyzing 419,497 semaglutide users and 77,259 tirzepatide users found substantially elevated vestibular disorder risk compared to matched controls
Current research suggests that tirzepatide, like GLP-1RAs, may enhance numerous cardiovascular risk factors
Pharmacologic studies in animals have shown that suppression of food intake after peripheral administration of the GLP-1 receptor agonists exendin-4 and liraglutide is mediated by activation of GLP-1R expressed on vagal afferents as well as direct CNS GLP-1R activation, highlighting the importance of the interaction between peripheral and central receptors [31]
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