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Polyethylene glycol-modified ultra-small silicon nanoparticles (C dots) for tumor imaging can bind and enrich iron ions, which can be endocytosed into cells and lead to an increase in intracellular iron content, causing iron metabolism disorders in tumor cells (267, 268)
The Phase 2 trial (Jastreboff et al., NEJM 2023) tested doses from 0.5mg to 12mg

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