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Description
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In rat models with ICV administration of STZ, ICV administration of adenovirus-mediated recombinant IGF-1 activated the IGF-1 signaling pathway, protected immature hippocampal neurons, inhibited tau protein phosphorylation, improved synaptic function and plasticity, increased hippocampal microglia with an anti-inflammatory role, and showed significant short-term improvements in recognition memory, spatial memory, and depression-like behavior [234]
Whats really happening is a combination of metabolic stress, nutritional changes, endocrine shifts, and unmasking of pre-existing vulnerabilities
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GLP-1 medications are designed to complementnot replacehealthy lifestyle habits
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