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Description
This article explores the science behind these agents.

Specifically, GLP-1 RAs showed significantly reduced risks of progression to systolic heart failure (HR 0.60) and stroke (HR 0.75) compared to SGLT2 inhibitors

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However, a sensitivity analyses suggests that these effects may be driven by the GLP-1 receptor agonist treatment.
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SMI strategies consider briefer stepwise surgical and medical treatments that can be deployed serially and/or concomitantly
