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Most clinical guidelines and obesity specialists recommend GLP-1 medications as long-term or indefinite treatments for obesity similar to how blood pressure or cholesterol medications are used chronically

Patients should attend scheduled appointments to assess HbA1c, renal function, and treatment tolerability

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Pennsylvania started paying for GLP-1 drugs for obesity in 2023
Neuroprotection by melatonin against ischemic neuronal injury associated with modulation of DNA damage and repair in the rat following a transient cerebral ischemia
Acknowledgements The authors thank Michael Bonar, Creative Director at the Leicester Diabetes Centre, for the original figure concept
