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Description
Background and aims: Biological differences between the sexes may influence the pathophysiology of some metabolic disorders, as well as the pharmacodynamics and pharmacokinetics of drugs
Weight loss can make surgery safer and reduce the risk of certain diseases
Conversely, TGF-RI upregulation exacerbates MASLD and fibrosis, as seen in models of SIX1 (Sine oculis homeobox homologue 1) or SHMT2 (Serine hydroxymethyl transferase 2) expression (Gao et al
Wegovy, also a weekly injectable, is FDA-approved specifically for weight loss
The first weeks are crucial for observation
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