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Variants in genes like FTO and MC4R can influence how quickly patients lose weight and how their metabolic rate adjusts to GLP-1 therapy

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Healthy endothelium is critical for preventing atherosclerosis (plaque build-up in arteries), and chronic metabolic disease damages it
Enhance Weight Loss Effects Semaglutide helps lower body weight by extending feelings of fullness and decreasing hunger

149151 In this regard, GLP-1 may inhibit K ATP channel activity within the Arc in order to regulate blood glucose homeostasis

Given the established cardiovascular benefits of dulaglutide and other incretin therapies, the investigators considered a placebocontrolled design unethical for patients with T2D and established ASCVD
