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While both compounds drive appetite suppression and insulin sensitization through GLP-1 and GIP pathways, Retatrutides GCGR activity delivers three additional effects: direct hepatic fat mobilization, increased thermogenesis, and accelerated lipid oxidation

It is contraindicated in patients taking monoamine oxidase inhibitors (MAOIs) or with hypersensitivity to amphetamine products

Mol Neurobiol 54:55505562 Craft S (2009) The role of metabolic disorders in Alzheimer disease and vascular dementia: two roads converged

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