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Neuroinflammation, driven by activated microglia and astrocytes, exacerbates tau pathology by releasing pro-inflammatory cytokines that promote tau hyperphosphorylation

Common gastrointestinal side effects include: Nausea (1222% of patients, dose-dependent) Diarrhea (1316% of patients) Vomiting (69% of patients) Constipation (67% of patients) Abdominal pain or discomfort (69% of patients) Decreased appetite (59% of patients) These effects are generally mild to moderate in severity and most pronounced during dose escalation

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