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But in general, these medications are very well tolerated and safe when prescribed appropriately. Still, McRae stresses that GLP-1s arent a magic solution

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The residues Arg158 and Asn164 of PCSK5 were crucial for its function

The presence of rectal bleeding or blood in the stool should always be investigated, as this is not an expected effect of either Wegovy or macrogol laxatives and may indicate other pathology requiring diagnosis

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