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The decision to combine these agents must be individualized based on patient-specific factors, including medical history, current medications, cardiovascular health, and response to previous weight management interventions

Not losing weight on Tirzepatide

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Cardiovascular outcomes and mortality after initiation of GLP-1 receptor agonists versus DPP-4 inhibitors: a nationwide study in patients with type 2 diabetes

Unlike native GLP-1, which breaks down within minutes in the body, semaglutide incorporates a fatty acid chain that enables binding to albumin