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We break down the key differences in mechanism, evidence base, side effects, and who each one is actually relevant for.

Orforglipron led to greater weight loss than semaglutide tablets and could offer more effective oral alternative to jabs

However, because glucagon-like peptide-1 receptor agonists work to slow gastric emptying, a safety concern has been raised in patients undergoing deep sedation or general anesthesia regarding gastric aspiration, and considering their long half-life in the blood, they are difficult to manage in the perioperative period

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