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RATIONALE FOR DUAL OR TRIPLE AGONISTS As described above, GLP-1 RA have proven efficacy and their use has increased steadily since their launch in 2005

In addition to needing long-term data in primary CV prevention populations, further research evaluating the CV effects of other GLP-1RA and SGLT2-I is required to understand whether such findings are agent or dose dependent

The link between GLP-1 and the heart also highlights the link between dementia and cardiometabolic disease, whereby risk reduction can pose as an additional effective mechanism in the treatment of AD [41]

Statistics Denmark obtained data from national Danish registries

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Res., vol