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These results were confirmed in rabbits that were initially sensitized with PGN by subcutaneous injection, followed by oral administration of 1% PGN in drinking water for 12 or 28 months (Kitano et al

Which is safer long-term

Potential Side Effects of GLP-1 While GLP-1 is generally well-tolerated, it's essential to be aware of potential side effects: Gastrointestinal Issues: Nausea, vomiting, diarrhea, constipation, and abdominal pain are the most common side effects, typically occurring in the initial stages of treatment and often subsiding over time

Furthermore, its short half-life of less than 3 h (Min et al., 2025) necessitates twice-daily injections to maintain efficacy, which can be a limiting factor for long-term patient adherence

Bergenstal, R.M., et al

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