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Most completed trials enrolled 30 to 90 participants

If hypokalemia is present, mineralocorticoid receptor antagonists (MRA) such as spironolactone or eplerenone are preferred

STEP (semaglutide) Clinical Trial: Most loss from fat mass

Patients taking ACE inhibitors or ARBsmedications that alter kidney hemodynamicsbenefit from baseline testing and periodic monitoring to ensure semaglutide is working synergistically rather than creating unintended interactions