can semaglutide cause high liver enzymes The weight-loss-independent hepatoprotective benefits of are orchestrated by intrahepatic sinusoidal endothelial GLP-1 receptors: Cell Metabolism Semaglutide-Induced Liver Injury - PMC

Clinical trials have shown increased rates of gallstones and cholecystitis, likely related to weight loss and altered bile composition

Halden TAS, Egeland EJ, sberg A, Hartmann A, Midtvedt K, Khiabani HZ, et al

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This keeps the plan evidence-led and reduces the risk of unnecessary or excessive supplementation

Duration Guidelines Based on Clinical Evidence Current medical guidelines recommend continuing GLP-1 therapy indefinitely for patients with obesity or weight-related metabolic conditions, similar to how blood pressure or cholesterol medications are managed long-term

Orlistat is the only drug of its kind that's approved in the U.S