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This review provides a comprehensive update of the regulation of midbrain dopamine circuits by peripheral feeding hormones, cataloging what is currently known about the mechanisms by which these hormones influence VTA activity and how these actions regulate food intake and behavior around drugs of a

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Emerging effects of DPP-4 on bone metabolism include an inverse relationship between DPP-4 activity levels and bone mineral density, along with an increased risk of fractures

+ : Appears to produce significantly more reduction in fat mass, and less in muscle mass

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