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Genetic Testing Reveals Your Personal Weight Loss Pathway Not everyone responds identically to GLP-1 therapy because genetic variation affects how your body processes appetite signals

ArmstrongMJGauntPAithalGPBartonDHullDParkerRet al

(2021), who have demonstrated that the ability of the GLP1 receptor agonists, liraglutide and semaglutide, to reduce food intake and body weight is not reduced by the ablation of PPG neurons and that chemogenetic activation of PPG neurons produced hypophagia in addition to that achieved with concurrent systemic administration of semaglutide

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Were targeting a separate satiety circuit the brainstem area postrema pathway that GLP-1 agonists alone dont fully engage

Moore, C