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Another trial, SOUL (NCT03914326), has now been initiated to overcome the shortcomings of PIONEER 6 with a primary endpoint focused at proving CV superiority vs placebo

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Food Chem Toxicol 152:112235

Early data are promising

Neutralizing Activin A decreases cell proliferation and adipocyte differentiation, revealing potential for therapeutic interventions

A supplementary analysis focusing specifically on retinopathy found consistent results, with semaglutide showing higher reporting odds compared to other drugs
