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Reduced inflammation: Once blood sugar levels are leveled, inflammation within the body decreases
But let's try a conservative scenario here

Semaglutide and tirzepatide both produce fatigue in their clinical trials at comparable rates
Research suggests these drugs lower the risk of developing substance use disorders and decrease addiction-related emergencies, hospitalizations, and deaths

However, context matters: Higher dose, higher effect: Semaglutides greater efficacy likely comes with proportionally more GI effects
The physics of pharmacokinetics simply require more time