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a) Coupling of Fmoc-Gly-OH with Resin in a solvent and a base by solid phase peptide synthesis to provide Fmoc-Gly-Resin, b) treating Fmoc-Gly-Resin with a deprotecting agent to provide H-Gly-Resin, c) coupling of Fmoc-Arg(pbf)-OH to H-Gly-Resin in a solvent optionally in presence of a coupling agent and/or a base to provide Fmoc-Arg(Pbf)-Gly-Resin, d) treating Fmoc-Arg(Pbf)-Gly-Resin with a deprotecting agent to provide H-Arg(Pbf)- Gly-Resin, e) repeating the coupling and deprotection steps with remaining amino acids Fmoc-Gly- OH, Fmoc-Arg(pbf)-OH, Fmoc-Val-OH, Fmoc-Leu-OH, Fmoc-Trp(Boc)-OH, Fmoc- Ala-OH, Fmoc-Ile-OH, Fmoc-Phe-OH, Fmoc-Glu(OtBu)-OH, Fmoc-Lys(Boc)-OH, Fmoc-Ala-OH, Fmoc-Ala-OH, Fmoc-Gln(Trt)-OH, Fmoc-Gly-OH, Fmoc-Glu(OtBu)- OH, Fmoc-Leu-OH, Fmoc-Tyr(tBu)-OH, Fmoc-Ser(tBu)-OH, Fmoc-Ser(tBu)-OH, Fmoc-Val-OH, Fmoc-Asp(OtBu)-OH, Fmoc-Ser(tBu)-OH, Fmoc-Thr(tBu)-OH, Fmoc- Phe-OH, Fmoc-Thr(tBu)-OH, Fmoc-Gly-OH, Fmoc-Glu(OtBu)-OH by linear approach as per the amino acid sequence in Semaglutide backbone in a solvent optionally in presence of a coupling agent and/or a base

Dietary restraint LSM changes from baseline in Dietary Restraint scores were generally not different at Week 24 or 36 in any treatment group, except for increases in the retatrutide 12 mg group (Week 24 LSM change 2.0