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11 This adverse effect may be related to GLP-1 R activation in the CNS, which can influence cerebrovascular tone and regional blood flow, potentially resulting in cerebral vasodilatation and headaches due to mechanical strain on pain-sensitive structures

doi: 10.1016/j.molmet.2022.101638 78 TurcotVLuYHighlandHMSchurmannCJusticeAEFineRSet al

Additionally, GLP-1 receptor agonists influence vascular autoregulation and may alter the delicate balance of blood flow control in susceptible individuals with anatomical risk factors

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Incapsula incident ID: 1849000640560022911-665251929889771578

This blog covers a recent Renegade Research Roundtable, two studies reporting on the effects of GLP-1 agonists on people with mast cell activation syndrome (MCAS) and intracranial hypertension, and two major GLP-1 long-COVID trials getting underway