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While current guidelines are clear regarding the benefits of GLP-1 RAs in patients with T2D, there is less clarity about how to adjust background therapies when initiating a GLP-1 RA

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Additionally, there is an immediate demand for the creation and application of reliable, standardized biomarkers of aging to assess therapeutic effectiveness not through clinical indicators of metabolic regulation, but through biological aging

These findings reveal a new role for natural gut GLP-1: it doesn't boost insulin release but instead sends a signal through gut nerves to make the body more responsive to insulin

Maintaining minimum caloric floors of 1,200 for women and 1,500 for men, with adequate protein, prevents this adaptation

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