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Right now, most of that is speculative

The trials showed meaningful weight loss at every dose level

Overlapping nausea might amplify discomfort

First, a substantial portion of the mechanistic and translational data derives from preclinical studies or small human cohorts, which may not fully capture understudied aspects of aging that vary across populations
The slightly lower weight loss compared to STEP HFpEF may reflect T2D-related metabolic differences, but the benefits across symptom, function, and inflammation domains remained robust
