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PRO Measures The SF-36v2 is a 36-item generic PRO measure used to assess general health status

The Lancet Neurology

Comparison of tirzepatide and dulaglutide on major adverse cardiovascular events in participants with type 2 diabetes and atherosclerotic cardiovascular disease: SURPASS-CVOT design and baseline characteristics

Similarly, for Zepbound (tirzepatide), fatigue was reported in 7.2-10.8% of patients (depending on dose) versus 4.1% in the placebo group

External review If both internal appeals fail, you have 4 months to request an external review by an independent review organization

Extended exposure: 24 hours to 7 days at room temperature This is where judgment calls become necessary