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Patient-specific factors that may increase risk include recent dose escalation, higher doses, significant gastrointestinal symptoms, diabetes-related gastroparesis, and autonomic neuropathy

FDA Roundup

It's all about demonstrating that you've explored other options and that this medication is the next logical step

E.EganJ

Additional hypotheses include the rapid correction of glycemia following GLP-1 RA administration, similar to the exacerbation of DR, as well as long-term effects of prior hyperglycemia via persistent changes in endothelial gene expression, often referred to as glucose memory [198,199]

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