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Therefore, the initiation of therapy with GLP-1RAs contributes to significant weight loss

and 0.4 (95% CI, 0.38-0.42) for tirzepatide

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2.3.2 Gut microbiota and its metabolites modulate GLP-1 secretion Emerging evidence highlights a bidirectional regulatory interplay between the gut microbiota and GLP-1, whereby microbial composition and metabolites exert profound influences on GLP-1 synthesis, secretion, and signaling

Also important: many people find that these symptoms improve after the body adapts (usually weeks 48)

You can also read our complete guide to Mounjaro in Australia to understand how it supports blood sugar control and long-term weight loss