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Data Availability Statement Data sharing is not applicable to this article as no new data were created or analyzed in this study.

The main concerns with GLP-1 agonist drugs include: GI side effects (nausea, diarrhea, vomiting, constipation, abdominal pain) High out-of-pocket cost for those who do not quality under insurance Risk of inadequate nutrition (reduced intake + insufficient nutrition counseling) Significant loss of muscle mass & bone density High discontinuation rates (with lost weight regained) Limited public & clinician knowledge on importance/implementation of nutrition and lifestyle changes Side Effects and Costs of GLP-1 Medications The use of GLP-1 drugs has been associated with numerous side effects, ranging from mild to severe

Offer subcutaneous semaglutide up to 1 mg once weekly for CV, renal and glycaemic benefits (no specific guidance on tirzepatide or oral semaglutide because CVOT results were unavailable at time of review)

Statement by an American association of clinical endocrinologists/American college of endocrinology consensus panel on type 2 diabetes mellitus: An algorithm for glycemic control

doi: 10.4103/1673-5374.320965 [DOI] [PMC free article] [PubMed] [Google Scholar] 99

Kidney targeting and modulating macrophage polarization through AMPK signaling: therapeutic mechanism of berberine in uric acid nephropathy