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Semaglutide has helped millions achieve significant weight loss by slowing stomach emptying and signaling satiety in the brain

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Wegovy (semaglutide) is a prescription GLP-1 medication initially approved by the Food and Drug Administration (FDA) for chronic weight management when combined with diet and exercise

Human studies have focused on weight loss and metabolic health rather than reproductive function

Notably, AGEs exposure significantly reduces sperm motility, particularly progressive motility ( 4 Damage to the environment surrounding spermatogenesis 4.1 Sertoli cell The number of SC in the adult testis determines daily sperm production, as each SC can maintain a limited number of germ cells ( in vivo and in vitro studies have demonstrated that high glucose levels upregulate Apelin (APLN) in SC, which subsequently downregulates cell junctionrelated genes such as connexin 43 (Cx43) and zonula occludens-1 (ZO-1), ultimately compromising the integrity of the BTB ( 4.2 Increased permeability of blood-testis barrier The bloodtestis barrier (BTB), also referred to as the SC barrier, is a critical structural and functional component of the seminiferous tubules

Your healthcare professional may also recommend cognitive-behavioral therapy or ADHD coaching