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doi:10.1200/JCO.2026.44.16_suppl.e12524

Liu C, Li C, Cai X, et al

Keywords: body composition, fat-free mass, glp-1 receptor agonists, lean mass, low testosterone, obesity pharmacotherapy, sarcopenia, skeletal muscle, testosterone replacement therapy Introduction and background Background Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have emerged as highly effective pharmacologic therapies for obesity and type 2 diabetes mellitus, producing substantial and sustained weight loss while improving cardiometabolic outcomes