tirzepatide and metformin together for weight loss Does Metformin Support Weight Loss?
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Side effects are typically mild and short-term

(3) POTENTIAL SERIOUS SIDE EFFECTS In some cases, Semaglutide may cause more serious side effects

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J Clin Invest 117:21552163 Shu L, Matveyenko AV, Kerr-Conte J, Cho JH, McIntosh CH, Maedler K (2009) Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

Severe gastrointestinal side effects from any GLP-1 medication can cause dehydration, potentially leading to acute kidney injury, so prompt medical review is advised if persistent vomiting occurs
