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Methods Sixteen participants with type 2 diabetes that was relatively well-controlled by metformin monotherapy were studied on four separate days in a crossover design

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Palpitations / reflex tachycardia Fatigue Less Common Side Effects Nausea, abdominal pain Sleep disturbances Muscle cramps or joint pain Gingival hyperplasia (gum overgrowth, rare but possible with chronic use) Serious (but Rare) Side Effects Severe hypotension Arrhythmias (very rare) Allergic reactions (rash, itching, swelling) Liver dysfunction (rare, but check if jaundice or dark urine develops) Key Point for Patients Most frequent complaint = ankle edema