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At the time studies had indicated that glucagon acted on the GLP-1r only at pharmacological concentrations (223) although other data suggested a more complex relationship and that glucagon could act on both glucagon and GLP-1r to regulate insulin secretion (155)

doi: 10.1016/j.eclinm.2023.101882 [DOI] [PMC free article] [PubMed] [Google Scholar] 25.Aronne LJ, Sattar N, Horn DB, et al

In contrast, during fasting and hypoglycemic conditions, GIP acts to increase glucagon secretion with little effect on insulin release

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Study: GLP-1 Agonists Are Associated With a Significant Reduction in Breast Cancer Incidence in Women

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