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Taking more than the recommended dose does not increase weight loss and significantly raises the risk of gastrointestinal side effects
Furthermore, the ileum of germ-free and antibiotic-treated mice showed lower Glp1r gene expression compared to controls, with higher incretin effect resistance (68)
Oxford, UK: Oxford University Press
J., Parkes D., Feigh M., Suschak J
From randomization to week 104, weight regain was +7.6 kg in placebo, +8.7 kg in liraglutide, +5.4 kg in exercise, and only +3.5 kg in the combination arm [15]
"Triple Hormone Receptor Agonist Retatrutide for Metabolic Dysfunction-Associated Steatotic Liver Disease: a randomised, double-blind, placebo-controlled, phase 2a trial." Nature Medicine , 2024
