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The indirect effects, mediated through reductions in HbA1c and body weight, appeared to explain 45.9% [95% CI 20.771.0%] of the decrease in UACR associated with tirzepatide relative to the pooled comparator and driven primarily by improved glycemic control, with no statistically significant role for weight reduction

On the contrary, Trujillo [16] denied higher incidence of biliary adverse events and acute pancreatitis with administration of GLP-1RAs in patients with T2D

Diabetes Obes Metab (2016) 18(3):24957.10.1111/dom.12602 9 Nuche-BerenguerBLozanoDGutierrez-RojasIMorenoPMarinosoMLEsbritPet alGLP-1 and exendin-4 can reverse hyperlipidic-related osteopenia

Doctors prescribe them as weekly injections

Nature Communications , 15 (1), 8498