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Funding This study was sponsored by Pfizer Inc

The mechanism(s) accounting for these beneficial effects is uncertain but is likely multifactorial with reductions in glycated hemoglobin, systolic blood pressure, postprandial triglyceride levels, inflammation, and the direct effect of activation of GLP-1 receptors in various tissues contributing

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A fully human monoclonal GIPR-Ab is specifically conjugated at the E384C positions to a GLP-1 agonist peptide analogue using a linker, resulting in two GLP-1 agonist peptides per antibody molecule (Fig