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You want to minimize how much nausea, fatigue, and GI effects interfere with your daily life

Chris Serres: So I think the idea is, at least with the program we wrote about, is it was almost like the, the medications were like training wheels, right

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Typical Semaglutide Titration Protocol: Weeks 1-4: 0.25 mg weekly (initiation dose) Weeks 5-8: 0.5 mg weekly if tolerated and appropriate Weeks 9-12: 1.0 mg weekly if continued escalation warranted Weeks 13+: 1.0-2.4 mg weekly maintenance based on individual response and goals Typical Tirzepatide Titration Protocol: Weeks 1-4: 2.5 mg weekly (initiation dose) Weeks 5-8: 5.0 mg weekly if tolerated Weeks 9-12: 7.5 mg weekly if appropriate Weeks 13+: 7.5-15 mg weekly maintenance based on clinical response Dose Adjustment Disclaimer: Titration schedules are individualized based on patient tolerance, side effect profiles, weight loss progress, metabolic response, and medical assessment

Simultaneous fat loss may be occurring, but water weight masks it on the scale

Shortages and expiry date of medicines and stringent regulatory requirements are key limiting factors driving the market