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Professor Hocking has received honoraria for lectures and/or manuscript writing from Lilly Australia, AstraZeneca, Amgen and Sanofi-Aventis, Nestl Health Sciences, iNova and Servier

The diabetes-versus-obesity nuance It is worth noting that in the REDEFINE 2 study of CagriSema in people with type 2 diabetes, the weight-loss magnitude was somewhat lower than in the non-diabetes REDEFINE 1 population a reminder that efficacy (and by extension any downstream liver benefit) is population-dependent, and that MASH patients, who frequently have diabetes, may respond differently than the leaner-metabolism trial populations

data curation, I.V.C., S.G.-M., L.E.D.-P

A new meta-analysis in *The Lancet* reveals a complex trade-off: Statins remain essential for preventing heart attacks and strokesbut they may modestly increase the risk of new-onset diabetes and worsening glycemia

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p = 0.24) to 7.54 (95% CI: 1.1913.89