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Effects of berberine on insulin resistance and serum adiponectin of nonalcoholic fatty liver patients

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Most patients can continue their levothyroxine without modification, but some require a modest increase in their thyroid hormone dose

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Due to trial shenanigans in Russia and Georgia (possible inclusion of ineligible patients, intervention groups not even receiving spironolactone, and uncertain outcome ascertainment) nicely detailed here (Pfeffer and Pitt, NEJM Evidence 2022), the official, hard EBM line remained that spironolactone does not work in HFpEF